Gene Links

Click here to see the Input Gene in :




Dot Plot for Cell Type


Corresponding Data for Cell Type




Dot Plot for Age


Corresponding Data for Age




Static Scatter Plot :

Graph for Sample grouped by Age


Corresponding Data for Sample grouped by Age




Click here to use the Heatmap option given below :


See Top Most Avg Gene Expression for a Particular Cell Type and corresponding Avg Expression of those Genes in the remaining Cell Types
Cluster the Heatmap by :

Heatmap




Heatmap Corresponding Data




Click here to use the Heatmap option given below :


See Top Most % Gene Expression for a Particular Cell Type and corresponding % Expression of those Genes in the remaining Cell Types
Cluster the Heatmap by :

Heatmap




Heatmap Corresponding Data




Average Expression : Sample D032

Percent Expression : Sample D032

Average Expression : Sample D046

Percent Expression : Sample D046

Average Expression : Sample D062

Percent Expression : Sample D062

Average Expression : Sample D088

Percent Expression : Sample D088

Average Expression : Sample D122

Percent Expression : Sample D122

Average Expression : Sample D139

Percent Expression : Sample D139

Average Expression : Sample D150

Percent Expression : Sample D150

Average Expression : Sample D175

Percent Expression : Sample D175

Average Expression : Sample D231

Percent Expression : Sample D231

About the Experiment


Respiratory failure associated with COVID-19 has placed focus on the lung. Here, we present single-nucleus accessible chromatin profiles of 90,980 nuclei and matched single-nucleus transcriptomes of 46,500 nuclei in healthy lung donors of ~30 weeks gestation, ~3 years and ~30 years. We mapped 398,395 candidate cis-regulatory elements (cCREs) in lung cell types and linked distal cCREs to putative target genes and leveraged this dataset to investigate loci associated with COVID-19. At the SARS-CoV-2 host entry gene TMPRSS2, we identified distal cCREs with age-increased activity in alveolar type 2 cells which had immune regulatory signatures and harbored variants associated with respiratory traits. At the novel 3p21.31 COVID-19 risk locus, a candidate variant overlapped a distal cCRE linked to SLC6A20, a gene expressed in alveolar cells which has known functional association with ACE2. Our findings provide insight into the gene regulatory logic of lung cell types including likely drivers of the increased expression of SARS-CoV-2 host genes in adults, and establish a resource (lungepigenome.org) for interpreting lung disease risk.

Link to the paper : https://elifesciences.org/articles/62522
Link to all the datasets : GEO: GSE161383

Related Links


Xin Sun lab homepage : http://xinsunlab.org
Kyle Gaulton lab : http://www.gaultonlab.org
UCSD Center for Epigenomics : https://medschool.ucsd.edu/som/cmm/research/epigenomics/pages/default.aspx
LungMAP : https://lungmap.net
Lungepigenome Website : https://www.lungepigenome.org/