Gene Links
Click here to see the Input Gene in :
Dot Plot for Cell Type
Dot Plot for Age
Static Scatter Plot :
Graph for Sample grouped by Age
Click here to use the Heatmap option given below :
See Top Most Avg Gene Expression for a Particular Cell Type and corresponding Avg Expression of those Genes in the remaining Cell Types
Click here to use the Heatmap option given below :
See Top Most % Gene Expression for a Particular Cell Type and corresponding % Expression of those Genes in the remaining Cell Types
Average Expression : Sample D032
Percent Expression : Sample D032
Average Expression : Sample D046
Percent Expression : Sample D046
Average Expression : Sample D062
Percent Expression : Sample D062
Average Expression : Sample D088
Percent Expression : Sample D088
Average Expression : Sample D122
Percent Expression : Sample D122
Average Expression : Sample D139
Percent Expression : Sample D139
Average Expression : Sample D150
Percent Expression : Sample D150
Average Expression : Sample D175
Percent Expression : Sample D175
Average Expression : Sample D231
Percent Expression : Sample D231
About the Experiment
Respiratory failure associated with COVID-19 has placed focus on the lung. Here, we present single-nucleus accessible chromatin profiles of 90,980 nuclei and matched single-nucleus transcriptomes of 46,500 nuclei in healthy lung donors of ~30 weeks gestation, ~3 years and ~30 years. We mapped 398,395 candidate cis-regulatory elements (cCREs) in lung cell types and linked distal cCREs to putative target genes and leveraged this dataset to investigate loci associated with COVID-19. At the SARS-CoV-2 host entry gene TMPRSS2, we identified distal cCREs with age-increased activity in alveolar type 2 cells which had immune regulatory signatures and harbored variants associated with respiratory traits. At the novel 3p21.31 COVID-19 risk locus, a candidate variant overlapped a distal cCRE linked to SLC6A20, a gene expressed in alveolar cells which has known functional association with ACE2. Our findings provide insight into the gene regulatory logic of lung cell types including likely drivers of the increased expression of SARS-CoV-2 host genes in adults, and establish a resource (lungepigenome.org) for interpreting lung disease risk.
Link to the paper : https://elifesciences.org/articles/62522
Link to all the datasets : GEO: GSE161383
Related Links
Xin Sun lab homepage : http://xinsunlab.org
Kyle Gaulton lab : http://www.gaultonlab.org
UCSD Center for Epigenomics : https://medschool.ucsd.edu/som/cmm/research/epigenomics/pages/default.aspx
LungMAP : https://lungmap.net
Lungepigenome Website : https://www.lungepigenome.org/
